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  • Ristela

    Increased sexual satisfaction

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  • Relizen

    Relief from menopausal hot flashes

  • Serenol

    Relief from emotional PMS

Relizen®

Safe, effective & non-hormonal relief of menopausal hot flashes for your patients who can't take hormones or don't want to take hormones.*


  • Reduces frequency & intensity of hot flashes and night sweats
  • Hormone-free and safe
  • Used by more than 1 million women worldwide
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A survey of over 3,500 patients shows Relizen provides relief of vasomotor symptoms*⁷

After just three months, women taking Relizen experience a reduction in frequency and intensity of hot flashes.

73%
Reduction in frequency
of hot flashes
71%
Reduction in intensity
of hot flashes
58%
Improved quality
of life
84%
Plan to continue
taking Relizen
SAFE, HORMONE-FREE, PLANT-BASED RELIEF OF MENOPAUSAL HOT FLASHES

We’ve unlocked the benefits of plant-based power

The ingredients in Relizen are made from a unique proprietary blend of highly purified flower pollen extract and have been shown in multiple published clinical studies to significantly improve menopausal symptoms.

Relizen is not a phytoestrogen and has no hormonal effect.¹‾³

In vitro data suggests the positive effects of Relizen on menopausal symptoms may be due to the inhibition of serotonin reuptake.⁴

Why Relizen?

Clinically effective

A randomized, double-blind, placebo-controlled trial in 54 women showed that Relizen significantly reduced hot flashes compared to placebo, with greater reductions over time ¹


After 3 months, 65% of patients taking Relizen experienced a reduction in their daily hot flashes ¹

Non-hormonal

Relizen relieves vasomotor symptoms with no hormonal effect* 1-3


 In an in vitro study

  • Relizen produced no proliferation of MCF-7 breast cancer cells, which are dependent on interaction with estrogen receptors, in contrast to 17-beta estradiol, which produced proliferation ³

 In a pre-clinical study

  • Relizen did not increase uterine weight even at 100x the equivalent human daily dose. In contrast, ethinyl estradiol increased uterine weight ²

 In a clinical study

  • Relizen showed no impact on measurements of estrogen, testosterone, FSH, and SHBG and showed no difference in breakthrough bleeding versus placebo¹

Safe and well-tolerated

Demonstrated safety in clinical trials and in real world experience


  • Across multiple double-blind, placebo-controlled trials, adverse events were no different from placebo
  • No inhibition of the CYP2D6 metabolic pathway, and no observed drug interactions 1,6
  • Safely used by more than 1 million women in europe, where it has been available for over 15 years5

Relizen is taken as two tablets, once per day, with or without food.

Talk to your patients about Relizen

Recommend Relizen to your patients who need a safe, effective, non-hormonal treatment for their hot flashes and night sweats associated with menopause.

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© 2021 Bonafide Health, LLC

Bonafide®, Ristela®, Relizen®, and Serenol™ and their associated logos are trademarks of Bonafide Health, LLC. Revaree® and its associated logo are the exclusively licensed trademarks of JDS Therapeutics, LLC, the parent company of Bonafide Health, LLC. All third party trademarks are the property of their respective owners. Bonafide Health, LLC products are protected by a number of patents including, but not limited to: U.S. Patent Nos: 6,669,967 C1; 6,569,471 C1; and 9,028,890.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
  • ¹ Winther K, Rein E, Hedman C. Femal, a herbal rememdy made from pollen extracts, reduces hot flashes and improves quality of life in menopausal women: a randomized, placebo-controlled, parallel study. Climacteric. 2005;8:162-170.
  • ² Hellström AC, Muntzing J. The pollen extract Femal—a nonestrogenic alternative to hormone therapy in women with menopausal symptoms. Menopause. 2012;19(7):825-829.
  • ³ Muñoz E. Effect of a PE-F/A on oestrogenic activity. VivaCell Biotechnology GmbH. Internal report. July 2012.
  • ⁴ Goldstein SR, Mischoulon D. Does Relizen, a non-hormonal treatment for the relief of menopausal hot flashes, work through a serotonergic mechanism of action? Menopause. 2015 Dec; 22(12):1383-1383.
  • ⁵ Data on File, JDS Therapeutics.
  • ⁶ Goldstein SR, Espié M, Druckmann R. Does Relizen, a non-hormonal treatment for vasomotor symptoms, inhibit the CYP2D6 enzyme system? Menopause. 2014;21(12):1320-1369.
  • ⁷ Goldstein SR, Veledar E, Perez Ojalvo S, et al. Menopause. 2017;24:14:1455.