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Building credibility with clinical data

Clinical trials determine if products really work and are actually safe

Unlike many supplement brands that don't test their products, Bonafide prioritizes safety and effectiveness by requiring clinical testing for all products. This approach gives customers and healthcare providers peace of mind knowing that our claims are supported by rigorous evidence.

  • Over 13,000 women have participated in Bonafide clinical studies and surveys†

40+ clinical trials and counting†

Here are a few of our most recent results.

Clairvee®

Clairvee® relieves vaginal odor, itching, and discharge in women without an infection in just 15 days with continued relief over 6 months. 1,5*
In a randomized, double-blind, placebo-controlled trial of 40 symptomatic patients without an infection on culture (nugent score of 4-6)

In an open-label trial of women with moderate-to-severe vaginal odor and no known infection:¹

0% 25% 50% 75% 100%

74% of women reported a reduction in vaginal odor at 2 weeks

0% 25% 50% 75% 100%

100% of women reported a reduction in vaginal odor at 6 months

% of women reporting a reduction in odor

In the same study, 93% of women studied reported that they prefer Clairvee to other OTC products for vaginal symptoms.¹

In a separate study, 75% of women reported improvements in vaginal itching and discharge vs. placebo in 15 days.⁵

Revaree®

Revaree®, replenishes vaginal moisture with a hormone-free formula featuring hyaluronic acid.

In a survey of more than 3,000 women, 96% of women plan to continue using Revaree.²³

Thermella™

Thermella™ relieves hot flashes and night sweats at the source for cooling relief in just two weeks (with results that improve over time).* 

In a clinical study of women taking Thermella, 60% experienced improved sleep and 97% experienced improved quality of life.⁵¹

Ristela®

Ristela® significantly improves sexual function across all stages of a woman’s life.7,8,9*

In an 8-week, open-label trial of pre, peri, and postmenopausal women with self-reported low sexual function:53

0% 25% 50% 75% 100%

84% reported improved physical arousal (n=40)

0% 25% 50% 75% 100%

75% reported they plan to continue using Ristela daily (n=40)

In three separate clinical studies, Ristela was shown to significantly improve Female Sexual Function Index (FSFI) scores after two months.

Serenol™

Serenol™ significantly reduces irritabillity, mood swings, uneasiness, and overall PMS severity*

In a separate survey of more than 500 women, 75% experienced relief within three months and 82% reported they plan to continue using Serenol¹⁶

Silvessa®

Silvessa® improves the health and appearance of hair and skin affected by estrogen decline during menopause.*

100% of women reported satisfaction with how healthy their facial skin looked.⁴² ⁵³

The gold standard in clinical trials

We use the gold standard of product testing: double-blinded placebo-controlled trials. Neither the participants nor the study team know who received the placebo or the supplement.

This rigorous research method is used to provide reliable and unbiased evidence of our product's effectiveness and safety. It helps healthcare providers make informed decisions about patient treatment and gives consumers confidence in the quality of the products they purchase.

Join our participant community

Our Bonafide research team is passionately committed to developing new formulations to further support women’s health. We invite you to join our participant community and discover how you can contribute to the testing of new products that address menopausal symptoms.

As a participant, you contribute to advancing women’s health research and gain an opportunity to access new innovative products before they come to market. Help us make a difference in the lives of countless women.

Join our community

Learn more about Bonafide

† Clinical trials were either conducted on Bonafide products or a key ingredient contained within Bonafide products.

¹ Results from an open-label clinical study. Full data on file.

⁵ Russo et al. Beneficial Microbes. 2019;10(1): 19-26.

⁷ Stanislavov and Rohdewald. J Women’s Health Care. 2014;3:6.

⁸ Bottari et al. Minerva Genecol. 2013;65:435-444. 8-week, active-controlled lifestyle study in 100 premenopausal women ages 37- 45.

⁹ Bottari et al. Panminerva Med. 2012;54:3-9. 8-week, randomized, single-blind, placebo-controlled study in 83 postmenopausal women ages 45-55.

¹⁴ Winther et al. Curr Ther Res Clin Exp. 2002;63(5):344-353.

¹⁶ Results are from an optional, rolling online survey, conducted from July 2016 through November 2017, that included 290 customers who were taking Serenol for at least 3 months. Patients who completed the survey were compensated with a $10 gift card for their opinions about Serenol.

²³ Dweck et al. A National Survey on Patient Satisfaction and Use Trends with Revaree, a Hyaluronic Acid Suppository, for Vaginal Dryness. The Journal of Sexual Medicine. 2022.

⁴² Kalman et al. J Clin Exp Dermatol Res, 2021;12(1):551.

⁴⁹ Data on file based on a pooled analysis of two double-blind, placebo-controlled clinical trials.

⁵¹ Lederman et al. Menopause. (Forthcoming) 2024. Full data on file. Sleep data based on 12-week results.

⁵³ Sylla et al. Current Developments in Nutrition. 2021:5:Supplement_2:374.