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Does Hyaluronic Acid for Vaginal Dryness Really Work?

Mercey Livingston

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Hyaluronic acid is one of the most popular ingredients in skincare products, but it turns out the benefits extend well beyond your face. Many women experience vaginal dryness and painful sex as they go through menopause, but traditionally estrogen creams are the main vaginal dryness treatment. Hyaluronic acid is a clinically studied, effective, naturally occurring ingredient that is also used to manage vaginal dryness and the associated symptoms like burning, irritation, and painful sex. Hyaluronic acid for vaginal dryness, offers relief without having to use hormone therapy – making it a viable alternative for women.

“Hyaluronic acid is naturally produced in the body. This is a key molecule involved in maintaining the skin’s moisture. Hyaluronic acid has the unique capacity to bind to and retain water, however, with age, comes natural depletion,” says Bonafide Chief Medical Officer, Dr. Alyssa Dweck. "A steep decline begins after the age of 40 – this is due to decreased production of the hyaluronic acid by our cells, " says Dr. Dweck. Keep reading for everything you need to know about hyaluronic acid, including the ingredient benefits, if hyaluronic acid is safe for vaginal use and how a vaginal moisturizer with hyaluronic acid can help relieve vaginal dryness.

What Is Hyaluronic Acid for Vaginal Dryness and How Is It Made?

Hyaluronic acid is found naturally throughout the body, including in the skin and joints. It has the natural ability to bind and retain water, which is why it's so great for hydrating the skin. The word "acid" might make you think that it's a harsh ingredient, but it's actually very hydrating.

In order to create Revaree®, a hormone-free, steroid-free and paraben-free hyaluronic acid vaginal suppository, Bonafide uses a unique, proprietary process to create this key ingredient without any animal-based ingredients or by-products.

"Traditionally, hyaluronic acid was sourced from rooster combs, the red part of the top of the rooster head, which is kind of odd, but it's super high in hyaluronic acid," says Bonafide Chief Science Officer, Jim Komorowski. "More recently, over the years, technology has found a way to have it synthesized from bacteria. And so, you can microbially generate and mass produce hyaluronic acid," says Komorowski.

According to Komorowski, hyaluronic acid can be somewhat difficult to absorb into the skin. However, Bonafide uses a special type in their hyaluronic acid vaginal suppositories, called sodium hyaluronate, that is more easily absorbed into the dermal layer of skin but does not get absorbed into the bloodstream.

Are Hyaluronic Acid Vaginal Suppositories Good for Vaginal Dryness?

The hormonal shifts associated with menopause can cause a lot of things to change – including sex and vaginal comfort. Reduced estrogen levels can cause vaginal dryness and discomfort with sex, which is why a topical vaginal moisturizer can help reduce dryness and pain. “Vaginal dryness naturally occurs with diminished estrogen levels. Less estrogen, which happens during menopause, leads to less blood flow to the vaginal tissues. Less blood flow means less natural lubrication and potential for uncomfortable symptoms including vulvar dryness, dry vaginal skin, and painful intercourse,” says Dr. Dweck.

Many women have traditionally used estrogen prescription products, such as vaginal gels or creams to help remedy vaginal dryness, but some women, like those with a history of some types of cancer, may not be able to or want to use hormonal therapies. “First, hyaluronic acid has been shown in multiple studies to be quite effective in treating vaginal dryness and painful sex and is safe for topical use in the vagina.In fact, studies2 have suggested equal efficacy of hyaluronic acid vaginal suppositories to vaginal estrogen without any hormone exposure,” says Dr. Dweck. “Many women cannot or will not take hormone therapy. For example, those with hormonally sensitive cancers, such as breast or uterine cancers, will typically avoid estrogen exposure.”

One of the benefits of using hyaluronic acid in a vaginal moisturizer is that it can be repeatedly used safely when taken as directed. “Vaginal moisturizers, including those made with hyaluronic acid, can be used indefinitely. Unlike hot flashes or night sweats, vulvar dryness and vaginal dryness related to menopause will only persist or worsen with time if not managed regularly. The longer a vaginal moisturizer is used, the better the outcome,” says Dr. Dweck. “Estrogen cream is effective and recommended indefinitely; however, that is a hormonal option with associated caveats.” Another added benefit of using a hyaluronic acid vaginal suppository like Revaree, is that it’s less messy than vaginal gel for vaginal dryness or products with applicators.

How Does a Hyaluronic Acid Vaginal Suppository, Like Revaree, Work?

Revaree is a simple to use insert that is applied vaginally. "Once the suppository melts, you're going to get an initial coating that could provide instant relief. And then, as the hyaluronic acid builds up in the tissues, it'll be able to bind more and more moisture," says Komorowski. This explains why some women see great results with using this vaginal moisturizer over time.

“Hyaluronic acid works by holding onto water to replenish and maintain moisture. In clinical studies, hyaluronic acid was shown to help maintain a normal, acidic vaginal pH, maintain the normal cellular architecture seen with estrogen,3 and relieve symptoms associated with vaginal dryness during menopause,” adds Dr. Dweck.

Is a Vaginal Moisturizer with Hyaluronic Acid Safe for Vaginal Use?

Hyaluronic acid for vaginal use is generally very safe and effective for most women, unless you have a known sensitivity. “Hyaluronic acid can be used topically in the vagina and has been extensively researched in clinical studies. It has received FDA clearance. This ingredient is well tolerated and incredibly effective for so many women,” says Dr. Dweck. In addition, it’s safe for those who don’t want to use hormones or can’t use them.

What You Need to Know About Revaree, Using Hyaluronic Acid Vaginally, and Sex

First, Revaree is not just a sexual lubricant. "A moisturizer, such as Revaree, can be used regularly as part of a maintenance program to manage and prevent symptoms related to vaginal dryness. A vaginal moisturizer is used regardless of sexual activity. A vaginal lubricant, in contrast, is typically used on-demand during sexual play to facilitate comfort and pleasure," says Dr. Dweck.

Revaree should not be used with condoms. "Revaree is not compatible with natural rubber latex, polyurethane, or polyisoprene condoms. As with many vaginal moisturizers, if Revaree comes into contact with natural rubber latex, polyisoprene, or polyurethane condoms, it may weaken the integrity of the condom. This incompatibility is thought to be due to the glyceride component in Revaree and not the hyaluronic acid itself." says Dr. Dweck.

In terms of safety for a male sexual partner, Dr. Dweck says that Revaree is safe. "Unlike topical estrogen products that treat vaginal dryness, Revaree is non-estrogenic and has no known adverse effects for male partners."

You can also learn more about our upgraded formula of Revaree, with double the hyaluronic acid, Revaree Plus, here:



  1. Jokar A, et al. IJCBNM. 2016;4:69-78
  2. Shuai-Bin, Lui, et al. Gynecological Endocrinology. 2014.10:31:3, 208-213
  3. Chen J, et al. J Sex Med. 2013;10:1575-1584


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      This stuff is a life changer when it comes to sex after menopause. 🙏🙏🙏

      Alisha Trujillo on

      I was very apprehensive about trying this. The sound of hyaluronic acid was intimidating. But the atrophy was changing my life drastically. It was after talking to my doctor and reading the reviews that I decided to try. The ladies were correct (in reviews) after about 9 days I so about an 80 percent improvement. It’s not messy at all and it is relieving. I’ve tried everything but it was only helpful for that intimate moment. I would recommend

      Lisa on

      I just started using this product and it’s amazing and it really works and I will continue to use it

      Tonya on

      Revaree is revolutionary in helping my body readjust to aging and allowing natural processes to be enhanced. Initially trying estrogen creams filled with synthetic ingredients giving me a not so pleasant discharge. Revaree comes closest to what I remember from years ago. So very highly recommended from this 70 year old!

      Nikki on

      I am now 66 and with through the change early I order this product because I was having trouble with dryness and being uncomfortable with being with my husband and I felt so bad. I use the product and it was a blessing. It really works . Thank you so much

      Brenda on

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