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Hot Flash + Sleep System

Noctera™ and Thermella®

Noctera: 180 tablets | 3-month supplyThermella: 180 tablets | 3-month supply

Meet the Hot Flash + Sleep System, featuring Thermella® and Noctera™—two hormone-free solutions that work together to decrease menopausal hot flashes and reduce sleep disruptions.*

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How it works: Noctera

The hormonal changes during perimenopause and menopause disrupt the body's sleep-wake cycle. Noctera is uniquely formulated to rebalance the naturally occurring chemicals that calm the mind for our best night's sleep.67

Made With

  • MAGNESIUM GLYCINATE In this highly bioavailable form, magnesium glycinate blocks the signals keeping you awake. This rebalances your sleep signals to help you stay asleep longer (and fall back asleep faster).67,70
  • GABA A calming neurotransmitter, GABA activates natural sleep signals to calm the mind and promote better sleep.67,68
  • L-THEANINE L-theanine blocks the excitatory glutamate pathway that keeps us awake, rebalancing the sleep-wake cycle to help calm the mind for a better night's sleep.67,69
  • SAMe Noctera is the only sleep supplement designed specifically for menopausal women that features SAMe, an ingredient that works to rebalance the calming and excitatory signals that contribute to hormone-related sleep disruptions.67

Ingredients

Noctera is a hormone-free, non-sedative sleep supplement with a continuous-release, non-groggy formula. It combines GABA, L-theanine, magnesium glycinate, and SAMe—each carefully selected to help rebalance hormonal signals that disrupt sleep patterns and to calm the mind for a better night's rest.

Key Ingredients: 

Magnesium (as magnesium glycinate), GABA (gamma-aminobutryic acid), SAMe (S-adenosyl L-methionine disulfate P-toluenesulfonate), l-theanine, propyl gallate.

Other ingredients:
Microcrystalline cellulose, methacrylic acid copolymer, silicon dioxide, stearic acid, magnesium stearate, hydroxypropyl methylcellulose, sodium starch glycolate, color (calcium sulfate, magnesium carbonate), triethyl citrate, isomalt, glycerin, glycerol monostearate, polysorbate 80.

How to use

Take two tablets of Noctera once daily, 60 minutes before bedtime, with a glass of water, and with or without food. For best results, use consistently each night. Results improve with continued use.

Quality & safety

At Bonafide, we are committed to ensuring our products are both safe and effective. Noctera is hormone-free, non-GMO, and rigorously tested for quality, purity, and potency.

Read more about our quality and safety >

What to expect

For maximum benefit, use Noctera daily and continuously, as it is not an on-demand treatment. Noctera starts working as early as one week, though most women begin to notice and feel improvement in two to three weeks. Results with Noctera continue to improve over time. We recommend taking Noctera for at least two to three months to maximize sleep benefits.

Learn more about Noctera

“I found Noctera to be a big help by providing a restful and calm method to getting a better night’s sleep. I woke refreshed and was able to focus on the upcoming day.”

TRISHA, REAL NOCTERA™ Clinical Trial Participant

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How it works: Thermella®

Thermella is the first plant-based supplement to target hot flashes at the source: NKB—or neurokinin B, a peptide that causes hot flashes & night sweats.*

Made With

  • Curcumin extract A naturally occurring compound found in turmeric with antioxidant properties, curcumin directly targets the source of hot flashes and night sweats in our body's thermoregulatory center.48,51*
  • Green tea extract Our proprietary formula contains decaffeinated green tea extract, which targets signals that cause hot flashes while also providing antioxidant benefits and supporting cellular metabolism.*
  • Spirulina extract A type of blue-green algae, spirulina is a nutrient-rich seaweed extract containing phycocyanin. Spirulina has been shown to provide numerous health benefits, including helping to rebalance the hormonal signals that cause hot flashes.*

Ingredients

Our hormone-free, naturally derived formula contains a unique combination of curcumin, spirulina, and decaffeinated green tea extract. This patented blend is safe, effective, and clinically tested to target hot flashes for precision cooling relief.

Amount per two tablets:

Longvida® Curcumin Extract, 600 mg

Decaffeinated± Green Tea Extract, 150 mg

Spirulina Extract, 85 mg

± Contains less than 5 mg of naturally occurring caffeine.

Other ingredients:

Microcrystalline cellulose, stearic acid, maltodextrin, lecithin, coating (rice starch (color), isomalt, hydroxypropyl methylcellulose, medium chain triglycerides, color (spirulina, caramel, carmine), d-trehalose, croscarmellose sodium, silica, ascorbyl palmitate, magnesium stearate.

How to use

Take two tablets once per day, with or without food.

Quality & safety

At Bonafide, we are committed to ensuring our products are both safe and effective. All of our products are free of hormones, parabens, soy, gluten, and GMOs. 

Every product is clinically tested. Together with our FDA-registered, Good Manufacturing Practices manufacturing facility, we rigorously test our products for consistency, quality, purity, and potency.

Read more about our quality and safety >

What to expect

In clinical trials, Thermella starts reducing hot flashes and night sweats as early as two weeks. Relief improves with consistent use, with best results at month three.49,50

Learn more about Thermella®

“I used to suffer from frequent night sweats and hot flashes that would have me waking up almost every hour. When taking Thermella that number was cut down by over half.”

Mary, Thermella® clinical trial participant

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  • Thermella
    Customer Reviews

We’re creating a new standard for women’s health

We've spent years rigorously researching, sourcing, and testing the purest ingredients to create safe and effective solutions—no hormones necessary.

Read about our science

Let’s talk

Got questions? We’ve got answers. Reach out to our support team—we’re here to help you make the most of your menopause journey.

Primary sources

Noctera™ and Thermella® are backed by rigorous research from scientific leaders in women's health.

48 U.S. Patent 11,779,627, FIG. 1-2.

49 Data on file based on a pooled analysis of two double-blind, placebo-controlled clinical trials.

50 Mason et al. Menopause. (Forthcoming) 2024a. Full data on file.

51 Lederman et al. Menopause. (Forthcoming) 2024. Full data on file.

52 Sahin et al. Current Developments in Nutrition. 2023a; 7: 209-210.

64 Carbonneau et al. Sleep. 2025;48(Supplement_1):A402-A403. A randomized, double-blind, placebo-controlled clinical study with 127 women. Sleep disturbances and sleep quality measured using the PROMIS-SD T-score. Full data on file.

65 Carbonneau et al. Sleep. 2025;48(Supplement_1):A402-A403. A randomized, double-blind, placebo-controlled clinical study with 127 women. Full data on file.

66 Data on file based on a three-month open-label clinical study of Noctera with 85 women

67 Bernsley et al. Sleep. 2024;47(Supplement_1):A97–A98. Full data on file.