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Does Your Dad's Family History Affect Your Menopause Experience? Here's What Research Says

Does Your Dad's Family History Affect Your Menopause Experience? Here's What Research Says

If you’ve started discussing menopause with your healthcare provider, chances are high that your mother’s menopause history has come up as a talking point. 

But what about paternal menopause history? Does your father’s side of the family have anything to do with when or how you’ll experience menopause?

There’s no straightforward answer, but here we’ll review how genetics—from both sides of the family—can play a role in menopause timing and potentially if there are any factors you can control to manage symptoms once they appear.  

Why Genetics Matter in Menopause

There’s no predicting your exact menopause experience but knowing when your family members started menopause may give you insight into when and (potentially) how you’ll experience menopause yourself, according to research.1

It turns out that age of menopause and risk for early menopause are highly heritable, with studies estimating a genetic influence between 40% and 85%.2 This means that, while lifestyle factors still impact hormonal health and the menopause experience, a woman’s genetic makeup can also play a role in determining when menopause occurs. 

According to one study, two specific genes—CHEK1 and CHEK2—play key roles in regulating DNA repair in ovarian cells, potentially influencing how quickly a woman’s egg supply declines over time.3 In other words, these specific genes may speed up or slow down how quickly your ovaries age, which can impact when menopause begins. 

Similarly, early research has explored SULT1A1, a gene involved in how the body processes estrogen. Differences in this gene may explain why some women experience more severe menopause symptoms like hot flashes, night sweats, and sleeplessness.4 However, this research is still developing and the science around how genes specifically impact menopause symptom type and severity is still in its early stages.

Paternal Menopause Family History and What It Means for Inherited Menopause Age

There’s research suggesting that your biological mother’s menopause age may influence your own menopause timing, but what does science have to say about your father’s medical history?5

Unfortunately, very little research mentions paternal menopause family history as a factor in determining future menopause experiences. However, here’s what we do know about menopause-related genetics:6, 7, 8, 9, 10

  • Genes come from both parents. Science shows menopause-related genes are found on the body’s normal chromosomes, which means the genetic basis for menopause involves many genes inherited from both your biological mother and father.
  • Maternal menopause age is a more common discussion topic. When discussing menopause symptoms, a healthcare provider may ask about your biological mom’s menopause age. Why? One possible reason is that it’s easier for women to track and report than looking back an additional generation. But even though paternal genetics are included less often in research or patient–provider discussions, they may also contribute to how and when you experience menopause.

Understanding Menopause Genetics: What’s Next?

While you can’t change your paternal menopause family history or genetics, research also suggests that positive lifestyle choices can influence how and when you experience menopause symptoms.11 Several lifestyle changes you can consider to potentially ease menopause symptoms include: 12,13,14,15,16,17

  • Regular exercise. Regular exercise may help manage sleeplessness, weight gain, hot flashes, mood swings, and more. It may also help lower the risk for chronic conditions associated with midlife, such as heart disease, diabetes, and osteoporosis.
  • A healthy diet. A diet that includes lean proteins, nutrient-dense fruits and vegetables, fiber-rich whole grains, and healthy fats may help you maintain a healthy weight, manage menopause symptoms, improve gut health and blood sugar levels, and lower your risk for heart disease—all health markers associated with increased age and/or menopause.
  • Manage stress levels. Keeping stress levels low helps to lower cortisol, a stress hormone that, in excess, interferes with estrogen and progesterone production in perimenopause. High stress levels can make menopause symptoms like hot flashes, sleep problems, and mood swings worse.
  • Limit alcohol and caffeine. Alcohol and caffeine may trigger hot flashes and exacerbate sleep issues in some women navigating menopause.
  • Avoid or quit smoking. Studies show smoking lowers estrogen levels, potentially leading to early menopause and more severe symptoms like hot flashes, night sweats, and mood swings.

Resources

  1.  https://sph.umich.edu/news/2021posts/genetic-influences-on-menopause-symptoms.html
  2. https://pmc.ncbi.nlm.nih.gov/articles/PMC3000672/
  3. https://www.nature.com/articles/s41586-021-03779-7
  4. https://journals.lww.com/menopausejournal/fulltext/2016/08000/influence_of_sult1a1_genetic_variation_on_age_at.9.aspx
  5. https://pmc.ncbi.nlm.nih.gov/articles/PMC2856641/
  6. https://pubmed.ncbi.nlm.nih.gov/22613007/
  7. https://www.nature.com/articles/s41586-021-03779-7
  8. https://www.nature.com/articles/s41586-021-03779-7
  9. https://pubmed.ncbi.nlm.nih.gov/23136135/
  10. https://pubmed.ncbi.nlm.nih.gov/18779679/
  11. https://pmc.ncbi.nlm.nih.gov/articles/PMC3955043/
  12. https://www.urmc.rochester.edu/news/publications/health-matters/why-exercise-is-essential-during-menopause
  13. https://www.eatright.org/health/wellness/healthful-habits/nutrition-and-menopause
  14. https://pubmed.ncbi.nlm.nih.gov/32068682/
  15. https://themenopausecharity.org/information-and-support/symptoms/menopause-and-stress/
  16. https://www.sciencedirect.com/science/article/abs/pii/S0378512212001855
  17. https://womenshealth.gov/menopause/early-or-premature-menopause

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