Noctera Clinical Trials: Sleep Support Studies for Menopause

Noctera® CLINICAL TRIALS

The clinical evidence behind Noctera^®

Noctera is a daily supplement designed to help with sleep disruptions caused by the hormonal changes that occur during perimenopause and menopause.* Below is a summary of the clinical evidence supporting the efficacy of Noctera.

4 clinical studies
Includes randomized, double-blind placebo controlled trial
Data published in peer-reviewed, indexed journal

Noctera has been evaluated in four clinical studies involving women with sleep disturbances. One of these studies has had results published, including in SLEEP (the official journal of the sleep research society).

Bonafide requires clinical testing for most products. This approach gives both our customers and healthcare providers confidence that our products are safe and effective and that our claims are supported by rigorous evidence.

Noctera® TRIAL 1

88% of women with moderate-to-severe sleep disturbances reached normal levels in 3 weeks

In a randomized, double-blind, placebo-controlled study of Noctera with 127 women conducted over three weeks, Noctera reduced sleep disturbances in as early as one week. 88% of patients with moderate-to-severe sleep disturbances improved to “within normal limits” by week three. And 83% of participants reported improved sleep quality. Total sleep time increased in the Noctera group by 40 minutes vs. decreased by 15 minutes in the placebo group by week three.

Carbonneau et al. Sleep. 2025;48(Supplement_1):A402-A403. Sleep disturbance (perceived difficulty falling or staying asleep and dissatisfaction with sleep quality) was measured via the PROMIS Sleep Disturbance, a validated patient-reported questionnaire assessing sleep disturbance over the prior 7 days. Scores are standardized T-scores; higher scores indicate greater disturbance (<55 normal, 55–59 02 mild, 60–69 moderate, ≥70 severe). Full data on file.

Find the study

RCT
randomized, double-blind, placebo-controlled trial
127 women
study size
Published
in SLEEP, the official journal of the Sleep Research Society

Noctera® TRIAL 2

Sleep quality continued to improve over three months of use

In an open-label trial with 85 patients, sleep quality continued to improve with 3 months of use, with 88% of women reporting improved sleep satisfaction. When patients stopped taking Noctera, sleep quality worsened, showing that this product works best when used consistently long-term. In this study, Noctera was determined to be non-habit forming and non-sedative.

Open-label clinical trial. Data on File.

Open label
open-label clinical trial
85 women
study size
Long-term
sleep outcomes

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What is Noctera?: Noctera is a clinically studied supplement carefully formulated with magnesium, GABA, L-Theanine, and SAMe, which work together to reduce sleep disturbances caused by hormonal changes and improve overall sleep quality.
How does Noctera work?: Noctera is uniquely formulated to target sleep disruptions caused by hormonal changes – the underlying reason many women struggle to stay asleep. By helping rebalance the body’s natural sleep signals, Noctera improves sleep quality and helps women sleep better through the night and wake up restored.
How long does it take for Noctera to work?: Some women taking Noctera felt improvements as early as one week, though most begin to notice and feel improvement in two to three weeks. Results with Noctera continue to improve over time, and we recommend taking Noctera for at least three months to experience the full sleep benefits.
Does Noctera have any side effects?: In a double-blind, placebo-controlled trial, side effects of Noctera were comparable to placebo, and no serious adverse events were reported. However, every woman is different and if you have specific concerns, you should speak with your doctor or healthcare practitioner.
How do I know if Noctera is right for me?: Noctera is intended for perimenopausal and menopausal women experiencing sleep challenges in the night.
Is Noctera a sedative?: Noctera is not a sedative and is not intended to assist with falling asleep. Instead, it supports sleep quality and sleep maintenance by reducing sleep disturbances and helping women return to sleep more easily when awakenings occur.
How often should I take Noctera?: Noctera is not an on-demand treatment and should be taken daily for maximum benefit.
Are Bonafide products covered by health insurance? By Medicare/Medicaid?: At this time, our products are not covered by traditional insurance. That said, some healthcare HSA or FSA cards cover part or all of the cost of certain Bonafide products. Through our partnership with Truemed, you can take a brief health survey to determine your eligibility. Upon completion, a licensed provider will review to see if your order qualifies for HSA/FSA. If approved, you will receive a Letter of Medical Necessity (LMN) via email within 48 hours.
What’s the best way to place my FSA or HSA order?: The HSA/FSA process differs for one-time versus subscription purchases. Click here for a guide on each process.

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The clinical evidence behind Noctera^®

88% of women with moderate-to-severe sleep disturbances reached normal levels in 3 weeks

Sleep quality continued to improve over three months of use

Learn more about Noctera

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Thermella relief from hot flashes

The clinical evidence behind Noctera®

88% of women with moderate-to-severe sleep disturbances reached normal levels in 3 weeks

Sleep quality continued to improve over three months of use

Learn more about Noctera

Want to know more?

Add your free gift

Thermella relief from hot flashes

The clinical evidence behind Noctera^®