Thermella® CLINICAL TRIALS

The clinical evidence behind Thermella®

Thermella is a once-daily supplement designed to aid with perimenopausal and menopausal hot flashes and night sweats. It uses the strength of curcumin, spirulina, and decaffeinated green tea extract to address symptoms without hormones. Below is a summary of the clinical evidence supporting the efficacy of Thermella.


  • 4 clinical studies
  • Includes randomized, double-blind placebo controlled trial
  • Published in indexed journals

Thermella has been evaluated in four clinical studies involving women with hot flashes and night sweats. Below is a sample of the clinical evidence supporting the efficacy of Thermella.

Bonafide requires clinical testing for most products. This approach gives both our customers and healthcare providers confidence that our products are safe and effective and that our claims are supported by rigorous evidence. 

Thermella® TRIAL 1

91% experienced an improvement in moderate to severe hot flashes

In a randomized, placebo-controlled trial of 65 women, 91% experienced an improvement in moderate to severe hot flashes.

Lederman, et al. Maturitas. 2026; 211(109023).

FIND THE STUDYOpens in a new window.
  • RCT

    randomized, double-blind, placebo-controlled trial

  • 65 women

    study size

  • 91%

    improvement in moderate to severe hot flashes

  • Published

    in Maturitas

Thermella® TRIAL 2

89% of women experienced better sleep

In an open-label trial of 112 women, 89% of women experienced better sleep after 3 months. And, 95% of women would recommend Thermella to a friend.

Alesi et al. Menopause. 2025;32(12):P-5. Full data on file.

FIND THE STUDYOpens in a new window.
  • Open label

    open-label clinical trial

  • 112 women

    study size

  • 89%

    of women experienced better sleep

  • Published

    in Menopause

Learn more about Thermella

See the full product page, ingredients, and how to get started.

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