Revaree® & Revaree® Plus CLINICAL TRIALS

The clinical evidence behind Revaree® and Revaree® Plus

Revaree and Revaree Plus are hyaluronic inserts formulated to aid vaginal dryness and painful intimacy. Below is a summary of the clinical evidence supporting its efficacy. 


  • 6 clinical trials + 2 online surveys
  • Includes randomized control trials on hyaluronic acid, the main ingredient in Revaree and Revaree Plus
  • Peer-reviewed & published in indexed journals

Hyaluronic acid, like that found in Revaree and Revaree Plus, has been evaluated in six clinical studies involving women with vaginal dryness and pain during intimacy. The results of these studies have been published in four peer-reviewed journals including the Journal of Menopause, the Journal of Sexual Medicine, International Journal of Community Based Nursing and Midwifery, and in the Journal of Menopausal Medicine.

Bonafide requires clinical testing for most products. This approach gives both our customers and healthcare providers confidence that our products are safe and effective and that our claims are supported by rigorous evidence. 

Revaree Plus for Vaginal Dryness

Revaree® Plus TRIAL 1

100% of women experienced vaginal dryness relief

In an open label trial of 168 women, 100% of women reported vaginal dryness relief after using Revaree Plus. Additionally, 98% of women reported irritation relief and 87% of women reported pain relief.

Open label clinical trial. Internal report.

  • Open label

    open-label clinical trial

  • 168 women

    study size

  • 100%

    of women reported vaginal dryness relief

Revaree® Plus TRIAL 2

Revaree Plus works as early as 1 week

In an open-label trial of 70 women, the study found Revaree Plus to work in as little as one week, and 95% of patients prefer Revaree Plus to other products on the market.

Kellogg-Spadt S, et al. Menopause. 2024.

FIND THE STUDYOpens in a new window.
  • Open label

    open-label clinical trial

  • 70 women

    study size

  • 7 days

    time to relief

  • Published

    in Menopause

Revaree® Plus Survey

92% of women report improved daily comfort with Revaree Plus

In an optional, online rolling survey in 2,066 patients who were using Revaree Plus for at least one month, 92% of women reported improved daily comfort with Revaree Plus.

Britton M et al. Menopause. 2025

  • Survey

    optional rolling survey by Bonafide

  • 2k+ women

    survey size

  • 92%

    reported improved daily comfort

Revaree® TRIAL 1

Revaree is as effective as topical estrogen in relieving vaginal dryness

In a randomized, controlled, head to head clinical trial in 49 women, Revaree was shown to be comparable to topical estrogen in reducing symptoms and 91% of patients reported symptom relief with Revaree.

Agrawal et al. Menopause. 2024;31(9):750-755

FIND THE STUDYOpens in a new window.
  • RCT

    randomized, controlled, head to head clinical trial

  • 49 women

    study size

  • 91%

    reported symptom relief with Revaree

Revaree® TRIAL 2

Hyaluronic acid like that in Revaree reduces vaginal dryness by 84% within 30 days

In a randomized, controlled, head to head clinical trial in 144 women, hyaluronic acid relieved vaginal dryness in as early as 9 days. After 30 days, vaginal dryness reduced by 84%. Hyaluronic acid was shown to be comparable to topical estrogen in reducing vaginal dryness.

Chen et al. The Journal of Sexual Medicine. 2013;10:1575–1584.

FIND THE STUDYOpens in a new window.
  • RCT

    randomized, controlled, head to head clinical trial

  • 144 women

    study size

  • 9 days

    time to relief

Revaree® TRIAL 3

Hyaluronic acid in Revaree reduced vaginal dryness by 56%

In a randomized, controlled clinical trial on 56 women, hyaluronic acid reduced vaginal dryness by 56% and was shown to be comparable to topical estrogen in reducing vaginal dryness.

Jokar et al. International Journal of Community Based Nursing and Midwifery. 2016;4(1):69–78.

FIND THE STUDYOpens in a new window.
  • RCT

    randomized, controlled clinical trial

  • 56 women

    study size

Revaree® TRIAL 4

Hyaluronic acid in Revaree reduced vaginal dryness by 62%

In a randomized, controlled clinical trial on 91 women, hyaluronic acid reduced vaginal dryness by 62% and was shown to be comparable to topical estrogen in reducing vaginal dryness.

Ilhan et al. Journal of Menopausal Medicine. 2021;27(1):15

FIND THE STUDYOpens in a new window.
  • RCT

    randomized, controlled clinical trial

  • 91 women

    study size

Revaree® Survey

85% of women report symptom relief with Revaree

In a survey of over 3,000 women using Revaree, 85% reported symptom relief, 72% reported improved quality of life, and 96% planned to continue using Revaree.

Dweck, et al. The Journal of Sexual Medicine. 2022;19.Supplement_3: S26-S26.

FIND THE STUDYOpens in a new window.
  • Survey

    optional rolling survey by Bonafide

  • 3k+ women

    survey size

  • 72%

    reported improved quality of life

Learn more about Revaree Plus

See the full product page, ingredients, and how to get started.

SHOP REVAREE PLUS