Serenol™ CLINICAL TRIALS

The clinical evidence behind Serenol

Serenol is a once-daily supplement formulated to provide relief from the emotional symptoms of estrogen decline experienced during PMS and menopause. Serenol combines our proprietary blend of Swedish flower pollen with chromium picolinate and expertly purified royal jelly. Below is a summary of the clinical evidence supporting the efficacy of Serenol.


  • 2 clinical studies on the ingredients in Serenol & 1 online survey
  • Includes randomized, double-blind placebo controlled trial
  • Peer-reviewed & published in 2 indexed journals

Serenol has been evaluated in two clinical studies and one online survey involving women with hormonal mood changes.

Bonafide requires clinical testing for most products. This approach gives both our customers and healthcare providers confidence that our products are 
safe and effective and that our claims are supported by rigorous evidence. 

Serenol for PMS Symptoms

Serenol™ TRIAL 1

Serenol increases control over appetite and reduces cravings

In a randomized, placebo-controlled trial of 42 adult women on 1000 mcg of chromium picolinate, women experienced increased control over appetite and reduced cravings for fatty foods.

Anton et al. Diabetes Technol Ther. 20008;10(5):405-412. Anton Et Al's inclusion criteria did not stipulate women had a diagnosis of PMS; rather, this study was conducted on healthy, overweight women

FIND THE STUDYOpens in a new window.
  • RCT

    randomized, double-blind, placebo-controlled trial

  • 42 women

    study size

  • Published

    in Diabetes Technology & Therapeutics

Serenol™ SURVEY

82% of women plan to continue using Serenol

In an online rolling survey with over 290 women taking Serenol, 82% plan to continue using it.

Results are from an optional, rolling online survey, conducted from July 2016 through November 2017, that included 290 customers who were taking Serenol for at least 3 months. Patients who completed the survey were compensated with a $10 gift card for their opinions about Serenol.

  • Survey

    optional rolling survey by Bonafide

  • 290 women

    survey size

  • 82%

    of women plan to continue using Serenol

Serenol™ TRIAL 2

Women experienced a 41% reduction in uneasiness and mood swings on Serenol

In a randomized, double-blind, placebo-controlled crossover trial of 32 women, the key ingredients in Serenol (Swedish flower pollen and royal jelly) were found to reduce uneasiness and mood swings by 41%, with a 33% reduction in irritability.

Winther K, et al. Curr Ther Res Clin Exp. 2002;63(5):344-355

FIND THE STUDYOpens in a new window.
  • RCT

    randomized, double-blind, placebo-controlled crossover trial

  • 32 women

    study size

  • Published

    in Current Therapeutic Research

Learn more about Serenol

See the full product page, ingredients, and how to get started.

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